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The effect of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on changes in myocardial energy and carbohydrate metabolism during ischemia was studied. Ischemia was induced by ligating the left anterior descending coronary artery for 3 or 30 min during open-chest surgery in anesthetized dogs. The myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered by 3 and 30 min of ischemia, indicating that anaerobic myocardial metabolism had occurred. Amosulalol (0.3 or 1 mg.kg-1) was injected intravenously 5 min before ischemia. Pretreatment with amosulalol, particularly at a dose of 0.3 mg.kg-1, reduced the myocardial energy depletion and the alteration of carbohydrate metabolism induced by ischemia. This result indicates that amosulalol can reduce ischemic influences on the myocardium.
N Hayase, and
K Chiba, and
K Ichihara
August 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
N Hayase, and
K Chiba, and
K Ichihara
October 1984,
Archives internationales de pharmacodynamie et de therapie,
N Hayase, and
K Chiba, and
K Ichihara
August 1990,
Japanese journal of pharmacology,
N Hayase, and
K Chiba, and
K Ichihara
May 1985,
Japanese journal of pharmacology,
N Hayase, and
K Chiba, and
K Ichihara
June 1990,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
N Hayase, and
K Chiba, and
K Ichihara
August 1986,
Japanese journal of pharmacology,
N Hayase, and
K Chiba, and
K Ichihara
November 1982,
European journal of pharmacology,
N Hayase, and
K Chiba, and
K Ichihara
February 1987,
Archives internationales de pharmacodynamie et de therapie,
N Hayase, and
K Chiba, and
K Ichihara
August 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
N Hayase, and
K Chiba, and
K Ichihara
October 1978,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
