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The effects of leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) on blast progenitors from acute myeloblastic leukemia (AML) were examined using a blast colony assay in a serum-free culture system. LIF and IL-6 stimulated colony growth in 2 and 5, respectively, of 11 cases studied. The simultaneous addition of LIF with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3) or IL-6 produced a statistically significant increase of colony numbers in 3, 6 and 7 of 11 cases, respectively. Numbers of colonies increased significantly when IL-6 was added simultaneously with GM-CSF or IL-3 in 5 and 4 of 11 cases, respectively. LIF or IL-6 used in the primary culture did not significantly change the numbers of secondary colonies compared to GM-CSF. Previous exposure to LIF and IL-6 did not alter cellular phenotype or morphology, indicating that LIF and IL-6 did not induce the differentiation of fresh AML blasts.
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
June 2015,
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
July 1993,
Blood,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
April 1989,
Proceedings of the National Academy of Sciences of the United States of America,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
October 1998,
Leukemia research,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
April 1991,
Lymphokine and cytokine research,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
August 1988,
Blood,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
April 1993,
Leukemia,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
May 2019,
Zhonghua fu chan ke za zhi,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
December 1988,
Nature,
M Takanashi, and
T Motoji, and
M Masuda, and
K Oshimi, and
H Mizoguchi
January 1994,
Cancer research,
