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The ultrastructural localization of copper and zinc superoxide dismutase (Cu,Zn-SOD) and manganese superoxide dismutase (Mn-SOD) was investigated in normal human skin by the post-embedding immunogold staining method. Epidermal keratinocytes were positive for both Cu,Zn-SOD and Mn-SOD. The Cu,Zn-SOD was predominantly located in the cytoplasm with a slight labelling on the mitochondria. The basal cells were remarkably positive for Cu,Zn-SOD and the upper spinous or granular cells faintly positive for this enzyme. In contrast to Cu,Zn-SOD labelling, Mn-SOD labelling was mostly restricted to the mitochondria. A similar labelling pattern was observed in dermal fibroblasts, endothelial cells, melanocytes, and in various epidermal appendageal cells (i.e. outer root sheath cells, sweat ducts and eccrine sweat gland cells). Thus the subcellular localization of Cu,Zn-SOD and Mn-SOD in the skin was similar among various cell types. Although no evidence for the peroxisomal localization of Cu,Zn-SOD was obtained in the present study, this could be due to a marked fragility of peroxisome that has not been identified in epidermal keratinocytes.
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
December 1985,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
November 1991,
Human reproduction (Oxford, England),
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
June 1994,
Laboratory investigation; a journal of technical methods and pathology,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
August 1989,
The Journal of urology,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
January 2020,
Frontiers in medicine,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
December 1985,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
March 1993,
The Journal of pathology,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
April 1989,
The Histochemical journal,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
March 1986,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
T Kobayashi, and
N Saito, and
N Takemori, and
S Iizuka, and
K Suzuki, and
N Taniguchi, and
H Iizuka
January 1992,
Human reproduction (Oxford, England),
