-transparent.png){kind=logo}
The expression of intercellular adhesion molecule-1 (ICAM-1) on the hepatocyte membrane was studied in 27 patients with chronic hepatitis B and C (CHB, CHC) by immunostaining using a monoclonal antibody. ICAM-1 was expressed focally in a honeycomb-like pattern by hepatocytes in livers of 26/27 patients. The degree of ICAM-1 expression was closely related to the ALT level and the histological grade of liver damage. Abundant cytotoxic T cells (CD8+, CD11b-) were found in ICAM-1-positive areas of the liver. Zones of focal necrosis contained both ICAM-1-positive hepatocytes and cytotoxic T cells. The expression of ICAM-1 was decreased in 4/6 CHB patients after interferon-alpha therapy. No relationship between the degree of hepatocyte ICAM-1 expression and viral replication markers (DNA polymerase activity and the presence of HBcA in the liver) was observed in patients with CHB. In addition, no positive correlation was found between the distribution of ICAM-1-positive hepatocytes and HBcAg-positive hepatocytes. These results suggest that ICAM-1 may play an important role in the pathogenesis of hepatocellular injury mediated by cytotoxic T cells in CHB and CHC.
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
May 2008,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
November 1993,
Journal of clinical pathology,
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
July 1990,
Hepatology (Baltimore, Md.),
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
January 1997,
Archives of virology,
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
January 2004,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
January 1996,
Hepato-gastroenterology,
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
January 2003,
Hepato-gastroenterology,
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
October 1997,
Journal of molecular endocrinology,
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
April 1994,
Transplantation proceedings,
N Horiike, and
M Onji, and
I Kumon, and
M Kanaoka, and
K Michitaka, and
Y Ohta
August 2000,
Neuropathology and applied neurobiology,
