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We have generated an 18-interval contiguous genetic linkage map of human chromosome 4 spanning the entire short arm and proximal long arm. Fifty-seven polymorphisms, representing 42 loci, were analyzed in the Venezuelan reference pedigree. The markers included seven genes (ADRA2C, ALB, GABRB1, GC, HOX7, IDUA, QDPR), one pseudogene (RAF1P1), and 34 anonymous DNA loci. Four loci were represented by microsatellite polymorphisms and one (GC) was expressed as a protein polymorphism. The remainder were genotyped based on restriction fragment length polymorphism. The sex-averaged map covered 123 cM. Significant differences in sex-specific rates of recombination were observed only in the pericentromeric and proximal long arm regions, but these contributed to different overall map lengths of 115 cM in males and 138 cM in females. This map provides 19 reference points along chromosome 4 that will be particularly useful in anchoring and seeding physical mapping studies and in aiding in disease studies.
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
June 1992,
Genomics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
January 1989,
Genomics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
March 1993,
Genomics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
August 1991,
American journal of human genetics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
April 1994,
Mammalian genome : official journal of the International Mammalian Genome Society,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
October 1988,
American journal of human genetics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
March 1991,
Genomics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
September 1990,
Genomics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
January 1992,
Cytogenetics and cell genetics,
P A Locke, and
M E MacDonald, and
J Srinidhi, and
T C Gilliam, and
R E Tanzi, and
P M Conneally, and
N S Wexler, and
J L Haines, and
J F Gusella
January 1985,
Annals of the New York Academy of Sciences,
