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Nitroglycerin reduces ischemic injury during acute myocardial infarction (AMI) in dogs--an effect that is potentiated when drug-induced hypotension and tachycardia are prevented with phenylephrine. To determine the effectiveness of nitroglycerin, alone or with phenylephrine, during AMI in man, 12 patients (five or whom had left heart failure) were evaluated by summing ST-segment abnormalities (sigmaST) from 35 precordial electrodes. The seven patients without heart failure did not benefit consistently from nitroglycerin alone; however, addition of phenylephrine to abolish nitroglycerin-induced arterial pressure reduction uniformly diminished sigmaST (4.9 to 3.2 mv; P less than 0.05). In patients with heart failure, nitroglycerin alone consistently reduced ischemia (5.8 to 4.4 mv, P less than 0.05); addition of phenylephrine often partially reversed this effect. Thus, administration of nitroglycerin, alone or with phenylephrine, can reduce myocardial ischemic injury during AMI in man; however, the response to phenylephrine depends on the presence or absence of left ventricular failure before treatment.
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
July 1987,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
January 1989,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
January 1999,
Giornale italiano di cardiologia,
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
March 1989,
The Canadian journal of cardiology,
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
April 1976,
The Medical letter on drugs and therapeutics,
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
November 1975,
The New England journal of medicine,
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
February 1974,
Circulation,
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
April 1992,
Hospital practice (Office ed.),
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
November 1976,
Circulation,
J S Borer, and
D R Redwood, and
B Levitt, and
N Cagin, and
C Bianchi, and
H Vallin, and
S E Epstein
October 1976,
The American journal of cardiology,
