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Amisulpride evaluation by radioreceptor assay comparison with HPLC procedure after single administration in the rabbit. 1993
R Mokrim, and
C Brunet, and
M Cazin, and
B Gressier, and
M Luyckx, and
T Dine, and
H Robert, and
J C Cazin
Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, Lille, France.
A radioreceptor assay (RRA) was developed to determine plasma levels of amisulpride. In in vitro binding conditions, the RRA technique was sensitive (11.6 nmol/l) and reliable, with a high degree of precision. The reproducibility of the method through statistical coefficients was < 7%. This method was applied to a pilot pharmacokinetic study in rabbits following single i.v. administration of amisulpride at 10 mg/kg. The results obtained were compared with those obtained by high performance liquid chromatography method (HPLC) in order to assess the validity of this new RRA technique.
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