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Innervation within the aging male rat pituitary neurointermediate lobe was examined using immunocytochemical methods with antisera to rate-limiting enzymes for serotonin (tryptophan hydroxylase, TpOH) or catecholamine (tyrosine hydroxylase TH) synthesis. Immunostaining for both enzymes was observed in both neural and intermediate lobes in younger rats (age 6 weeks or 7 months), but TpOH was absent from the intermediate lobe in older groups (10-12, 15-16, and 18-19 months). Colocalization of TpOH and TH was demonstrated in some nerve fibers, using immunofluorescence. The oldest age group showed a reduced staining pattern for TH. 5-hydroxytryptophan, the immediate precursor for serotonin (5-HT), was taken up and converted to immunoreactive 5-HT in all age groups. Overall, the pattern of staining for regulatory neurotransmitters or enzymes which ultimately affect pituitary intermediate lobe secretory function is significantly modulated during the aging process.
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
January 1982,
Proceedings of the National Academy of Sciences of the United States of America,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
December 1992,
Biochemical and biophysical research communications,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
September 2000,
Drug metabolism and disposition: the biological fate of chemicals,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
January 1988,
Journal of neuroscience research,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
February 1989,
Cell and tissue research,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
January 1986,
Neurobiology of aging,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
June 1994,
Histochemistry,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
August 1987,
Neuroscience letters,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
July 1977,
Brain research,
L C Saland, and
A Samora, and
P Sanchez, and
G Chavez
August 1977,
Brain research,
