Biomaterial Database

[Immunogenic activity of vaccines against rabies]. 1975

Z Cupera

The effectiveness of cerebrospinal avianized and tissue vaccines against rabies produced in Czechoslovakia was compared with that of some foreign vaccines. At the same time, the results obtained were compared with the international standard - vaccine obtained on request from the World Health Organization. The following methods were used for the determination of effectiveness: determination of the content of virus in vaccine in mice, effectiveness test in guinea-pigs -- Koprowski, effectiveness test and ED50 determination in mice -- our modification of Nazarov's method. The effectiveness of the Czechoslovak cerebrospinal vaccine was very good. The results were the same as in the case of the foreign vaccines (Soviet, Bulgarian) and the international standard vaccine used for comparison. The ED50 determined in these vaccines ranged from 2.49 mg to 8.0%. The avianized Czechoslovak vaccine showed higher effectiveness of foreign vaccines (Holland, Spain, Algeria). The immunogeneity index was 0.87--1.14. For the time being, tissue vaccines are produced in testing series in Czechoslovakia; nevertheless, they gave the same results as foreign vaccines (Soviet, French). The ED50 of tissue vaccines was found to range from 5.21 mg to 16.50 mg.

UI	MeSH Term	Description	Entries
D007928	Lethal Dose 50	The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.	LD50,Dose 50, Lethal
D009426	Netherlands	Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, and Sint Maarten, formerly included in the NETHERLANDS ANTILLES.	Holland,Kingdom of the Netherlands
D011818	Rabies	Acute VIRAL CNS INFECTION affecting mammals, including humans. It is caused by RABIES VIRUS and usually spread by contamination with virus-laden saliva of bites inflicted by rabid animals. Important animal vectors include the dog, cat, bat, fox, raccoon, skunk, and wolf.	Encephalitic Rabies,Furious Rabies,Hydrophobia,Paralytic Rabies,Lyssa,Furious Raby,Lyssas,Rabies, Encephalitic,Rabies, Furious,Raby, Furious
D011819	Rabies Vaccines	Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.	Rabies Human Diploid Cell Vaccine,Rabies Vaccine,Vaccine, Rabies,Vaccines, Rabies
D002031	Bulgaria	A country in Southeastern Europe, bordering the Black Sea, between Romania and Turkey. The capital is Sofia.
D003604	Czechoslovakia	Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.
D005602	France	A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.	Corsica,Saint Pierre and Miquelon,Miquelon and Saint Pierre,Miquelon and St. Pierre,St. Pierre and Miquelon
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000462	Algeria	A country in northern Africa bordering the Mediterranean Sea, between MOROCCO and TUNISIA. Its capital is Algiers.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia