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The alpha-2 adrenoceptor agonists, clonidine, guanabenz, and guanfacine, injected subcutaneously produced a dose-related diuresis. The maximal effect occurred at 2h after administration of clonidine 192 micrograms/kg or 960 micrograms/kg of guanabenz and guanfacine. The alpha-2 antagonist, yohimbine, in doses of 1-8 mg/kg administered prior to the agonists caused a dose-dependent decrease in urine output. The action of the three agonists at alpha-2 adrenoceptors was supported by the observation that the alpha-1 adrenoceptor agonist, prazosin (0.61-2.5 mg/kg), administered prior to each agonist caused an inconsistent decrease in the elevated urinary output caused by clonidine, guanabenz and guanfacine. These results indicate that stimulation of alpha-2 adrenoceptors causes diuresis in the rat.
D C Shockley, and
L H Wade, and
M M Williams-Johnson
August 1988,
The American journal of physiology,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
May 1995,
Annals of the New York Academy of Sciences,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
October 1992,
Journal of cardiovascular pharmacology,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
March 1987,
The Journal of pharmacology and experimental therapeutics,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
April 1996,
Research communications in molecular pathology and pharmacology,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
January 1992,
Pharmacology & toxicology,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
November 2011,
Upsala journal of medical sciences,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
June 1981,
European journal of pharmacology,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
January 1987,
Psychopharmacology,
D C Shockley, and
L H Wade, and
M M Williams-Johnson
January 1990,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
