Biomaterial Database

Effects of YM-14673, a new thyrotropin-releasing hormone analogue, on impaired learning of passive avoidance in mice. 1993

M Yamamoto, and Y Ozawa, and H Takeuchi

Institute of Applied Pharmacology and Development, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.

The effects of YM-14673(N alpha-([(S)-4-oxo-2-azetidinyl] carbonyl)-L-histidyl-L-prolinamide dihydrate), a new thyrotropin-releasing hormone analogue, on impaired passive avoidance responses, were studied in mice in comparison with those of the thyrotropin-releasing hormone and its analogue DN-1417. In a test trial 24 hr after training, the latency in entering into a darkened compartment from an illuminated one was shortened by scopolamine and cycloheximide treatment. The shortened latency was prolonged in both models when YM-14673, thyrotropin-releasing hormone and DN-1417, in doses without effect on spontaneous movement and pain response by the hot plate method, were administered before training. This prolongation of shortened latency by the thyrotropin-releasing hormone and its analogues in cycloheximide-treated mice was antagonized by scopolamine but not by haloperidol. YM-14673 was about 10 times more potent than the thyrotropin-releasing hormone and DN-1417 in improving the impaired learning behavior. The shortened latency of step-through was ameliorated in scopolamine-treated mice when YM-14673 was administered immediately after training but not before testing. These results suggest that YM-14673, in addition to the thyrotropin-releasing hormone and DN-1417, facilitates the cerebral functioning, presumably by activating the cholinergic system.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008813	Mice, Inbred ICR	An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER.	Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D010147	Pain Measurement	Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.	Analgesia Tests,Analogue Pain Scale,Formalin Test,McGill Pain Questionnaire,Nociception Tests,Pain Assessment,Pain Intensity,Pain Severity,Tourniquet Pain Test,Visual Analogue Pain Scale,Analog Pain Scale,Assessment, Pain,McGill Pain Scale,Visual Analog Pain Scale,Analgesia Test,Analog Pain Scales,Analogue Pain Scales,Formalin Tests,Intensity, Pain,Measurement, Pain,Nociception Test,Pain Assessments,Pain Intensities,Pain Measurements,Pain Questionnaire, McGill,Pain Scale, Analog,Pain Scale, Analogue,Pain Scale, McGill,Pain Severities,Pain Test, Tourniquet,Questionnaire, McGill Pain,Scale, Analog Pain,Scale, Analogue Pain,Scale, McGill Pain,Severity, Pain,Test, Analgesia,Test, Formalin,Test, Nociception,Test, Tourniquet Pain,Tests, Nociception,Tourniquet Pain Tests
D003513	Cycloheximide	Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.	Actidione,Cicloheximide
D004151	Dipeptides	Peptides composed of two amino acid units.	Dipeptide
D006220	Haloperidol	A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)	Haldol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001362	Avoidance Learning	A response to a cue that is instrumental in avoiding a noxious experience.	Aversion Behavior,Aversion Learning,Aversive Behavior,Aversive Learning,Avoidance Behavior,Aversion Behaviors,Aversive Behaviors,Avoidance Behaviors,Behavior, Aversion,Behavior, Aversive,Behavior, Avoidance,Behaviors, Aversion,Behaviors, Aversive,Behaviors, Avoidance,Learning, Aversion,Learning, Aversive,Learning, Avoidance
D001384	Azetidines