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The effects of some antiallergic drugs on H1-histamine, 5-HT2-serotonin, and M-cholinoreceptors ligand binding in the rat brain were studied in vitro. Dimedrol, dimebon, and phencarol bonded to H1-receptors: IC50 were 76 +/- 10, 153 +/- 15, 320 +/- 60 nM, respectively. Diazoline and dimebon had some affinity for 5-HT2-receptors, its IC50 was 880 +/- 90 nM. Dimedrol, phencarol and diazoline were found to be active against M-cholinoceptors, but when given in the maximal concentration (10 microM) it acted nonspecifically. In contrast to the other drugs, bicarphen had no effects on the binding of [3H]-mepyramine, [3H]-ketanserine, and [3H]-quinuclidinyl benzylate in the rat brain.
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
February 1981,
Journal of neurochemistry,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
October 1978,
Archives of biochemistry and biophysics,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
March 1980,
Neurochemical research,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
February 1987,
Journal of neurochemistry,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
October 1983,
Neuroendocrinology,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
January 1984,
Journal of neuroscience research,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
December 1979,
Biochemical pharmacology,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
June 1998,
The Tohoku journal of experimental medicine,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
March 1981,
Brain research bulletin,
E M Gankina, and
N V Porodenko, and
T I Kondratenko, and
E S Severin, and
M E Kaminka, and
M D Mashkovskiĭ
December 1983,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
