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Leukocyte traffic in immune-inflammatory responses requires regulated adhesion of leukocyte subsets to vascular endothelium. We show that fibrinogen or normal human plasma enhances by 2- to 5-fold the adhesion of cells of myeloid and lymphoid lineage to endothelium. This mechanism is mediated by fibrinogen binding to complementary membrane receptors on leukocytes and endothelial cells. Using an affinity chromatography purification strategy, genetically engineered transfectants, and direct binding studies to the isolated recombinant protein, we identified a novel hematopoietic fibrinogen receptor participating in this adhesion pathway as intercellular adhesion molecule 1 (ICAM-1). Accordingly, a new model can be proposed, in which fibrinogen binding to a variety of vascular cell receptors mediates a specific pathway of cell to cell adhesion by bridging together leukocytes and endothelial cells.
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
June 2003,
Thrombosis and haemostasis,
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
August 1998,
The American journal of physiology,
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
November 1992,
Journal of reconstructive microsurgery,
L R Languino, and
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A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
April 1989,
Journal of immunology (Baltimore, Md. : 1950),
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
September 1998,
American journal of respiratory cell and molecular biology,
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
January 2008,
Critical care (London, England),
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
January 1993,
The Journal of cell biology,
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
March 1996,
Journal of leukocyte biology,
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
January 1993,
Current topics in microbiology and immunology,
L R Languino, and
J Plescia, and
A Duperray, and
A A Brian, and
E F Plow, and
J E Geltosky, and
D C Altieri
June 1983,
The Journal of laboratory and clinical medicine,
