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In 31 patients undergoing coronary artery bypass grafting, we investigated the maintenance doses of pancuronium and vecuronium during hypothermic cardiopulmonary bypass. For all patients, the height of the first twitch of the train-of-four (T1) was measured with evoked electromyogram. During operation, T1 was kept from 5 to 15 per cent of control. Infusion doses of both muscle relaxants were controlled with a personal computer. During hypothermic cardiopulmonary bypass (body temperature 28 degrees C), requirement of both muscle relaxants decreased for about 90 per cent compared with pre bypass values. We consider that the prolongation of neuromuscular blockade is attributable to hypothermia rather than to other factors of cardiopulmonary bypass. After rewarming, maintenance dose of vecuronium remained about a half of the dose required in pre-bypass period. It suggests that elimination of vecuronium from liver and kidney is hindered not only during hypothermia but also after rewarming.
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
February 1985,
Anesthesiology,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
September 1986,
Anaesthesia,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
August 1983,
Anaesthesia and intensive care,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
December 2000,
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
September 1995,
Anesthesia and analgesia,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
February 1997,
Journal of cardiothoracic and vascular anesthesia,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
October 1995,
Journal of neurosurgical anesthesiology,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
January 1993,
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
January 1977,
Critical care medicine,
Y Ohnishi, and
O Uchida, and
T Nakajima, and
K Kitaguchi, and
O Takaki, and
H Ohsumi, and
M Kuro
April 1998,
Anesthesia and analgesia,
