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We investigated the adequacy of using dose and onset time as variables to predict the duration of action of vecuronium in patients. The onset time until 95% twitch depression and the duration until 25% twitch recovery were measured for doses ranging from 0.1 to 0.3 mg kg-1. Statistical analyses were performed by simple and multiple regressions. The duration of action was better predicted by dose (r2 = 0.61) than by onset time (r2 = 0.51). However, the predictability was significantly improved by a multiple regression model of the variables, and the explanatory power was largest when using the square root of duration as the dependent variable (r2 = 0.69). We conclude that the duration of neuromuscular blockade after vecuronium can be predicted more accurately by the combined use of dose and onset time than by dose alone.
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
August 1989,
Anesthesiology,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
April 1986,
Anaesthesia,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
January 1993,
Minerva anestesiologica,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
February 1991,
Anaesthesia and intensive care,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
August 2002,
Masui. The Japanese journal of anesthesiology,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
February 1990,
Masui. The Japanese journal of anesthesiology,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
October 2001,
The Tokai journal of experimental and clinical medicine,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
December 1988,
Anesthesiology,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
July 2003,
British journal of anaesthesia,
K Rørvik, and
P Husby, and
L Gramstad, and
J S Vamnes, and
O E Bøe
November 1995,
European journal of anaesthesiology,
