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BACKGROUND In phase II studies of the EORTC-ECTG, acute hypersensitivity reaction, edema and skin toxicity were important side effects of docetaxel (TaxotereTM). METHODS Fifty patients with solid tumors were treated with docetaxel at the University Hospital of Antwerp. Of these, 28% developed an acute hypersensitivity reaction and 20% edema. Twelve and three hours before the next docetaxel administrations those with the acute hypersensitivity reaction were subsequently pretreated orally with 32 mg of methylprednisolone, 10 mg of cetirizine and 1 mg of ketotifen. CONCLUSIONS The acute hypersensitivity reaction could be completely blocked in all but in 1 of 14 patients, and this pretreatment schedule had an important prophylactic effect on edema formation. Skin toxicity was successfully treated with an ointment of glycerin and chlorhexidine.
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
February 1998,
Expert opinion on investigational drugs,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
April 1995,
Seminars in oncology,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
January 2001,
Tumori,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
April 1997,
Intensive & critical care nursing,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
December 1999,
Japanese journal of cancer research : Gann,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
January 1993,
Cancer surveys,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
July 2012,
Current drug safety,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
June 1999,
Seminars in oncology,
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
January 1999,
Dermatology (Basel, Switzerland),
D Schrijvers, and
J Wanders, and
L Dirix, and
A Prove, and
I Vonck, and
A van Oosterom, and
S Kaye
September 1996,
The Medical letter on drugs and therapeutics,
