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Thirty-three patients with severe systemic hypertension defined as a diastolic blood pressure (DBP) > or = 120 mm Hg were randomized in a single-blind fashion to be treated with either intravenous fenoldopam mesylate (FNP) or sodium nitroprusside (NTP). Fenoldopam mesylate and NTP infusion rates began at 0.1 microgram/kg/minute and 0.5 microgram/kg/minute, respectively and were titrated to achieve a goal DBP of between 95 and 110 mm Hg; or a reduction of at least 40 mm Hg if the baseline DBP was > 150 mm Hg. Fenoldopam mesylate (n = 15) reduced blood pressure from 217/145 +/- 6/5 to 187/112 +/- 6/3 mm Hg (P < .001) at an average infusion rate of 0.5 +/- 0.1 microgram/kg/minute. The average time to achieve goal DBP with FNP was 1.5 +/- 1.4 hours. Nitroprusside (n = 18) reduced blood pressure from 210/136 +/- 5/2 to 172/103 +/- 6/2 mm Hg (P < .001) at an average infusion rate of 1.2 +/- .24 micrograms/kg/minute. Nitroprusside response time averaged 2 +/- 2.5 hours. There was no significant difference between the magnitude of effect seen with either FNP or NTP; nor was there any difference observed in the adverse effect rates of the two agents. Fenoldopam mesylate and NTP demonstrate similar overall efficacy in the treatment of severe systemic hypertension.
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
April 1989,
The American journal of cardiology,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
February 1990,
Hypertension (Dallas, Tex. : 1979),
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
May 1990,
Critical care medicine,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
April 1992,
The American journal of cardiology,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
April 1989,
Archives of internal medicine,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
November 1995,
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
March 1990,
Circulation,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
August 1990,
Anaesthesia and intensive care,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
May 2004,
The Annals of pharmacotherapy,
B L Pilmer, and
J A Green, and
E A Panacek, and
W J Elliot, and
M B Murphy, and
W Rutherford, and
A R Nara
December 1992,
Archives of internal medicine,
