-transparent.png){kind=logo}
In this paper, the synthesis and analgesic activities of some derivatives of 4-methoxycarbonyl fentanyl are reported, in which the 4-N-phenyl group or both the 4-N-phenyl group and the 1-beta-phenyl group were replaced by some nonaromatic groups. In the last case, some compounds showed very strong analgesic activity. For example, the analgesic activities of compounds 4 and 6 were shown to be 695 and 818 times more potent than that of morphine respectively. The structure-analgesic activity relationships were discussed.
Related Publications
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
January 1990,
Yao xue xue bao = Acta pharmaceutica Sinica,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
January 1990,
Yao xue xue bao = Acta pharmaceutica Sinica,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
January 1991,
Yao xue xue bao = Acta pharmaceutica Sinica,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
January 1992,
Yao xue xue bao = Acta pharmaceutica Sinica,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
September 2014,
Drug research,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
January 1992,
Yao xue xue bao = Acta pharmaceutica Sinica,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
November 1972,
Journal of pharmaceutical sciences,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
January 1990,
Yao xue xue bao = Acta pharmaceutica Sinica,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
December 1987,
Il Farmaco; edizione scientifica,
S T Wen, and
Y L Yang, and
H Z Shao, and
K G Zhang, and
Y L Li, and
J S Chen
December 1981,
Journal of medicinal chemistry,
