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Elevated levels of soluble ICAM-1 in sera from patients with bronchial asthma. 1993
S Hashimoto, and
K Imai, and
T Kobayashi, and
E Amemiya, and
Y Takahashi, and
Y Tomita, and
T Iwata, and
H Suguro, and
M Yamaguchi, and
A Yachi
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM-1 in sera reflect the upregulation of ICAM-1 expression in allergic inflammation.
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