Biomaterial Database

Relationship between post-tetanic twitch and single twitch response after administration of vecuronium. 1993

Y Saitoh, and H Toyooka, and K Amaha

Department of Anaesthesiology and Critical Care Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.

We have studied the relationship between post-tetanic twitch (PTT) and single twitch response after administration of vecuronium 0.2 mg kg-1 in 100 patients during neuroleptanaesthesia (NLA) (droperidol and fentanyl) and during anaesthesia with halothane, isoflurane, enflurane or sevoflurane (1 MAC in nitrous oxide and oxygen). Intervals from PTT1 to single twitch, and post-tetanic-count (PTC) (number of PTT responses) at the onset of single twitch were determined electromyographically. These intervals in the isoflurane, enflurane and sevoflurane groups differed from those in NLA and halothane groups. PTC in the isoflurane, enflurane and sevoflurane groups differed from those in the NLA group, and PTC in the sevoflurane group significantly from those in the NLA and halothane groups. These results are consistent with the view that PTT reflects prejunctional block, whilst the single twitch response is indicative of postjunctional block.

UI	MeSH Term	Description	Entries
D007530	Isoflurane	A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
D008297	Male		Males
D008738	Methyl Ethers	A group of compounds that contain the general formula R-OCH3.	Ethers, Methyl
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009458	Neuroleptanalgesia	A form of analgesia accompanied by general quiescence and psychic indifference to environmental stimuli, without loss of consciousness, and produced by the combined administration of a major tranquilizer (neuroleptic) and a narcotic.	Neuroleptoanalgesia
D009469	Neuromuscular Junction	The synapse between a neuron and a muscle.	Myoneural Junction,Nerve-Muscle Preparation,Junction, Myoneural,Junction, Neuromuscular,Junctions, Myoneural,Junctions, Neuromuscular,Myoneural Junctions,Nerve Muscle Preparation,Nerve-Muscle Preparations,Neuromuscular Junctions,Preparation, Nerve-Muscle,Preparations, Nerve-Muscle
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D004737	Enflurane	An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.	Alyrane,Enfran,Enlirane,Ethrane,Etran
D004987	Ethers	Organic compounds having two alkyl or aryl groups bonded to an oxygen atom, as in the formula R1–O–R2.
D005260	Female		Females