BIOMAT Database Logo BIOMAT Database Logo

Metachronous multifocal development of urothelial cancers by intraluminal seeding. 1993

T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Department of Urology, Faculty of Medicine, Kyoto University, Japan.

To investigate the clonal origin of multifocal urothelial tumours, we analysed the p53 tumour-suppressor gene in 3 cases with bladder tumours developing after treatment for a renal pelvic or ureteral tumour and in 1 case with a ureteral tumour after treatment for a bladder tumour. For each case, identical p53 gene mutations were detected in all primary and recurrent tumours. The results suggest that heterotopic recurrence by intraluminal seeding from the original tumour is common in urothelial cancer. The data also support the view that multifocal urothelial tumours are derived from a single progenitor cell.

UI MeSH Term Description Entries
D007680 Kidney Neoplasms Tumors or cancers of the KIDNEY. Cancer of Kidney,Kidney Cancer,Renal Cancer,Cancer of the Kidney,Neoplasms, Kidney,Renal Neoplasms,Cancer, Kidney,Cancer, Renal,Cancers, Kidney,Cancers, Renal,Kidney Cancers,Kidney Neoplasm,Neoplasm, Kidney,Neoplasm, Renal,Neoplasms, Renal,Renal Cancers,Renal Neoplasm
D008967 Molecular Biology A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules. Biochemical Genetics,Biology, Molecular,Genetics, Biochemical,Genetics, Molecular,Molecular Genetics,Biochemical Genetic,Genetic, Biochemical,Genetic, Molecular,Molecular Genetic
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D009366 Neoplasm Seeding The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation. Seeding, Neoplasm
D001749 Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014516 Ureteral Neoplasms Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom. Cancer of Ureter,Ureteral Cancer,Cancer of the Ureter,Neoplasms of Ureter,Neoplasms, Ureteral,Ureter Cancer,Ureter Neoplasms,Ureter, Cancer Of,Cancer, Ureteral,Cancers, Ureteral,Neoplasm, Ureteral,Ureter Cancers,Ureter Neoplasm,Ureteral Cancers,Ureteral Neoplasm
D016158 Genes, p53 Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53. Genes, TP53,TP53 Genes,p53 Genes,Gene, TP53,Gene, p53,TP53 Gene,p53 Gene
D018095 Germ-Line Mutation Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. Mutation, Germ-Line,Germline Mutation,Germ Line Mutation,Germ-Line Mutations,Germline Mutations,Mutation, Germ Line,Mutation, Germline,Mutations, Germ-Line,Mutations, Germline

Related Publications

T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract.
August 2001, Oncogene,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Are all metachronous multifocal urothelial carcinoma created equal?
May 2018, Translational andrology and urology,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding.
September 1999, British journal of cancer,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
[Multifocal development of urothelial tumors].
April 1978, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Papillary urothelial carcinoma in sigmoid neobladder suggesting 'intraluminal seeding' from ureter cancer.
October 2008, International journal of urology : official journal of the Japanese Urological Association,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation.
July 2007, British journal of cancer,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
[A Case Report of Metachronous Multiple Cancers Including Triple Lung Cancers, Gastric Cancer, and Double Urothelial Cancers].
December 2023, Gan to kagaku ryoho. Cancer & chemotherapy,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Multifocal metachronous osteogenic sarcoma.
August 1992, Australasian radiology,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Metachronous occurrence of multifocal phaeochromocytoma.
May 2011, Indian journal of pediatrics,
T Habuchi, and R Takahashi, and H Yamada, and Y Kakehi, and T Sugiyama, and O Yoshida
Metachronous colorectal cancers.
July 1998, The British journal of surgery,
Copied contents to your clipboard!