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We report a case of acute encephalopathy in a patient with Crohn's disease who had taken sulfasalazine for 1 month. The development of toxic hepatitis and dermatitis prompted interruption of the drug. Four days later, neurologic symptoms became evident. These included acute monoparesis of the left arm, the development of stupor and coma, with endorotation of both arms, and a left Babinski sign. CT and MR imaging revealed multiple lesions in the white and gray brain matter, suggesting diffuse cerebral microangiitis. All cerebrospinal fluid examinations were negative. Methylprednisolone was given intravenously. Complete clinical normalization followed. Neurotoxicity secondary to sulfasalazine has seldom been reported in the literature. We found certain similarities with two previous case reports suggesting a hypersensitivity reaction to sulfasalazine or one of its metabolites. For ethical reasons, no rechallenge was performed.
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
September 1982,
The American journal of gastroenterology,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
October 2022,
ACG case reports journal,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
January 2017,
Intestinal research,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
December 2012,
Harefuah,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
September 2023,
Cureus,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
January 2001,
Journal of neurology,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
July 1989,
The Journal of laboratory and clinical medicine,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
October 2006,
Der Anaesthesist,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
September 2016,
Journal of clinical gastroenterology,
R Schoonjans, and
A Mast, and
G Van den Abeele, and
D Dewilde, and
E Achten, and
V Van Maele, and
W Pauwels
April 2011,
Nutrition (Burbank, Los Angeles County, Calif.),
