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In the hope of increasing the incidence of objective remissions and the survival time of patients with small cell lung cancer, we conducted a randomized study designed to compare a treatment scheme of alternating chemotherapy featuring cisplatin+etoposide followed by cyclophosphamide+epirubicin versus conventional chemotherapy with cyclophosphamide+epirubicin+vincristine, in a total of 113 patients (56 treated with the alternating regime and 57 treated conventionally). Patients receiving the alternating drug regimen showed some increase in objective remission rates, and above all increased mean survival time (297 days versus 232). The higher incidence of side effects encountered was effectively controlled by the usual medical therapy.
A Farris, and
M Bisail, and
M G Sarobba, and
G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
June 2003,
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A Farris, and
M Bisail, and
M G Sarobba, and
G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
January 1994,
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A Farris, and
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C Intini
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C Intini
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G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
January 1992,
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A Farris, and
M Bisail, and
M G Sarobba, and
G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
September 1985,
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A Farris, and
M Bisail, and
M G Sarobba, and
G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
January 1990,
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A Farris, and
M Bisail, and
M G Sarobba, and
G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
October 1987,
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A Farris, and
M Bisail, and
M G Sarobba, and
G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
January 1982,
Cancer chemotherapy and pharmacology,
A Farris, and
M Bisail, and
M G Sarobba, and
G Sanna, and
T Scotto, and
S Valzelli, and
C Intini
January 1982,
Cancer chemotherapy and pharmacology,
