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Sites of the muscle relaxant action of CS-722 were investigated in rats. Doses injected intra-4th ventricularly (i.c.v.) or intrathecally (i.t.) were determined according to measurements of CS-722 concentration in the brain stem and the spinal cord after systemic administration. When administered i.c.v. (50 and 100 micrograms) or i.t. (200 and 400 micrograms), CS-722 reduced the radio frequency decerebrate rigidity, although the effect after i.c.v. injection was transient. These results indicate that CS-722 exerts its muscle relaxant action by affecting both the supraspinal structure and the spinal cord. Spinal reflexes were not affected by CS-722 injected i.c.v. It seems that muscle relaxation is not always accompanied by impairment of the spinal reflex.
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
October 1992,
Neuropharmacology,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
September 1992,
Neuropharmacology,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
March 1998,
General pharmacology,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
January 2006,
CNS drug reviews,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
September 1968,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
September 1975,
Neuropharmacology,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
November 1974,
Archives internationales de pharmacodynamie et de therapie,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
July 1992,
Chemical & pharmaceutical bulletin,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
January 1995,
European journal of pharmacology,
M Tanabe, and
H Ishizuka, and
T Murayama, and
T Kaneko, and
T Tonohiro, and
J Sakai, and
M Nagano, and
K Sasahara, and
N Iwata
November 1970,
Arzneimittel-Forschung,
