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OBJECTIVE To determine the effect of transdermal oestrogen replacement therapy on the haemostatic balance of menopausal women. METHODS Open, parallel group, prospective study. METHODS Three hospital-based menopause clinics. METHODS Fifty-two postmenopausal women receiving transdermal hormone replacement therapy (Estrapak 50) for 6 months. Comparison group of 48 untreated postmenopausal women studied in parallel. METHODS Changes in platelet number, plasma concentrations of coagulation factors and their natural inhibitors, fibrinolytic activity, and rheological parameters. RESULTS Estrapak 50 had no significant thrombophilic effect on any of the outcome measures. CONCLUSIONS The haemostatic balance and thus the risk of thrombosis would not appear to be upset by this dose of transdermal oestrogen.
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