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Three patients with eosinophilia-myalgia syndrome linked to consumption of L-tryptophan supplement developed a severe sensorimotor axonal neuropathy. All three had myalgia, elevated eosinophil count, and later developed fasciitis. Neuropathy was found at all stages of the illness and resulted in disability which was irreversible despite cessation of L-tryptophan. Nerve conduction studies showed reduced motor and sensory evoked response amplitudes with select sparing of some nerves and the arms were more involved than the legs. Cerebrospinal fluid protein content was increased in one of two patients so tested. Creatine kinase was normal and muscle biopsy showed perimysial inflammation. Sural nerve biopsy in one case showed epineural perivascular inflammation. Our data showed that a severe sensorimotor axonal neuropathy occurs in eosinophilia-myalgia syndrome, suggestive of mononeuritis multiplex.
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
October 1990,
Annals of neurology,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
April 1992,
International journal of dermatology,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
July 1992,
Nihon rinsho. Japanese journal of clinical medicine,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
April 1991,
The Western journal of medicine,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
June 1991,
Der Nervenarzt,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
July 1990,
New York state journal of medicine,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
March 1991,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
December 1992,
Mayo Clinic proceedings,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
November 1993,
Harefuah,
S M Burns, and
D J Lange, and
I Jaffe, and
A P Hays
June 1990,
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
