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The in vitro protein binding of flecainide was studied by equilibrium dialysis in relation to serum concentrations of albumin and alpha 1-acid glycoprotein (AAG) in 22 healthy subjects of both sexes aged between 23 and 89 years. In the range of flecainide concentrations tested, protein binding of flecainide was not saturable and the percent value of the unbound fraction ranged between 0.48 and 0.68, mean value (SD) = 0.59 (+/- 0.06), without any significant difference between males and females or between young and old subjects. The flecainide unbound fraction was significantly correlated with serum albumin concentrations but not with total serum proteins or AAG concentrations.
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
January 1984,
European journal of clinical pharmacology,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
October 1991,
British journal of clinical pharmacology,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
January 1995,
Infection,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
April 2008,
The Science of the total environment,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
April 1984,
British journal of clinical pharmacology,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
January 2005,
Journal of investigational allergology & clinical immunology,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
March 1984,
The Journal of pharmacy and pharmacology,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
January 1985,
The Journal of pediatrics,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
January 1974,
Eksperimentalna meditsina i morfologiia,
R Zordan, and
R Padrini, and
V Bernini, and
D Piovan, and
M Ferrari
September 2012,
Journal of psychiatric research,
