Biomaterial Database

Effects of dopamine on the carotid chemosensory response to hypoxia in newborn kittens. 1993

A Bairam, and B Hannhart, and C Choné, and F Marchal

Laboratoire de Physiologie, Faculté de Médecine, Université de Nancy, Vandoeuvre-les-Nancy, France.

In a previous study, it has been shown that bolus injections of dopamine could either stimulate or inhibit the carotid chemosensory discharge in the kitten (Marchal et al., 1992a). To further characterize dopaminergic mechanisms in the carotid body during development, the effects of a continuous infusion of dopamine on carotid chemosensory activity in air, hypoxia (8% O2 in N2) and hyperoxia (100% O2) were studied in ten anesthetized, paralyzed and artificially ventilated kittens, aged 1 to 21 days and in three adult cats. One carotid sinus nerve was prepared for recording the activity of a single or a few chemosensory afferents. In the kittens, the immediate effect of dopamine at the onset of infusion (10 micrograms/kg/min) was an inhibition of the discharge in five kittens, a progressive excitation in four and no change in one. Four minutes after the onset of dopamine infusion, there was a significant increase in chemosensory activity both in room air (from 4.5 +/- 0.8 impulse/sec to 8.8 +/- 1.4 impulse/sec, mean +/- SEM, P < 0.05) and in hypoxia (from 24.6 +/- 3.7 impulse/sec to 33.4 +/- 5.3 impulse/sec, P < 0.05) but not in hyperoxia (0.5 +/- 0.2 impulse/sec vs 0.7 +/- 0.3 impulse/sec). The adult cats received four successive dopamine infusions at the rate of 2.5, 5, 7.5 and 10 micrograms/kg/min, in an attempt to establish a dose-response relationship. The effects of dopamine infusions were consistent within, but variable between, cats. The onset of dopamine infusion was associated with an inhibition of the discharge in two cats, at all infusion rates. In one of them, chemosensory activity returned quickly to control and the response to hypoxia was enhanced. In the other cat, the inhibition of the discharge persisted for the duration of the infusion, and the response to hypoxia was inhibited. In the third cat, dopamine had no effect on the chemosensory discharge. The patterns of chemosensory responses evoked by dopamine are qualitatively similar in kittens and cats, but the excitatory type of response appear to be more readily elicited in the kitten.

UI	MeSH Term	Description	Entries
D007262	Infusions, Intravenous	The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.	Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002344	Carotid Body	A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.	Glomus Caroticum,Bodies, Carotid,Body, Carotid,Caroticum, Glomus,Carotid Bodies
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002628	Chemoreceptor Cells	Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.	Chemoreceptive Cells,Cell, Chemoreceptive,Cell, Chemoreceptor,Cells, Chemoreceptive,Cells, Chemoreceptor,Chemoreceptive Cell,Chemoreceptor Cell
D004298	Dopamine	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.	Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D000860	Hypoxia	Sub-optimal OXYGEN levels in the ambient air of living organisms.	Anoxia,Oxygen Deficiency,Anoxemia,Deficiency, Oxygen,Hypoxemia,Deficiencies, Oxygen,Oxygen Deficiencies