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A series of 110 muscle and 40 skin biopsy specimens were examined using direct immunofluorescence aiming to identify features that may differentiate the myopathy of connective tissue disease from other muscle diseases. The skeletal muscle fluorescence was positive in 75% of the patients with muscle diseases. The sarcolemmal staining was higher in mitochondrial encephalomyopathy. Fiber and vascular staining occurred in all muscle diseases, except in cases of myasthenia. Our results showed that 42% of patients with polymyositis and 43% of patients with peripheral motor neuron diseases have vascular deposits of immune complexes suggesting that these two diseases could result from an immune-complex-induced vasculopathy. The IF test in skin specimens was positive in 60% of the patients with muscular diseases. The absence of immunoglobulin deposit at the dermoepidermal junction and at epidermal nuclei in cases of peripheral motor neuron disease suggest that this skin test may be useful in the differentiation of muscle diseases.
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
September 1971,
Military medicine,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
January 1985,
Clinical and experimental rheumatology,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
January 1972,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
April 1983,
Human pathology,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
January 1993,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
January 1969,
Nihon rinsho. Japanese journal of clinical medicine,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
May 1976,
The Journal of dermatologic surgery,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
July 2022,
Dermatology practical & conceptual,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
March 2010,
Muscle & nerve,
C J Rodrigues, and
J A Levy, and
M Carvalho, and
A J Rodrigues Júnior, and
T E De Barros Filho, and
W Cossermelli
January 1979,
Brain & development,
