Biomaterial Database

[Expression of rat type 2C alpha protein phosphatase in Saccharomyces cerevisiae cells]. 1994

T Kobayashi, and M Ohnishi, and S Kato, and Y Sasahara, and S Tamura

Dept. of Biochemistry, Tohoku University.

In the course of a study to elucidate the physiological functions of type 2C protein phosphatase(PP2C), we investigated the effects of overexpression of the enzyme protein on the physiology of eukaryotes. In this study, we demonstrated that the overexpression of PP2C alpha caused a decreased growth rate and an increased UV-sensitivity of the yeast cells. We also showed that the expressed PP2C was phosphorylated by casein kinase II in the cells.

UI	MeSH Term	Description	Entries
D010749	Phosphoprotein Phosphatases	A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)	Phosphoprotein Phosphatase,Phosphoprotein Phosphohydrolase,Protein Phosphatase,Protein Phosphatases,Casein Phosphatase,Ecto-Phosphoprotein Phosphatase,Nuclear Protein Phosphatase,Phosphohistone Phosphatase,Phosphoprotein Phosphatase-2C,Phosphoseryl-Protein Phosphatase,Protein Phosphatase C,Protein Phosphatase C-I,Protein Phosphatase C-II,Protein Phosphatase H-II,Protein-Serine-Threonine Phosphatase,Protein-Threonine Phosphatase,Serine-Threonine Phosphatase,Threonine Phosphatase,Ecto Phosphoprotein Phosphatase,Phosphatase C, Protein,Phosphatase C-I, Protein,Phosphatase C-II, Protein,Phosphatase H-II, Protein,Phosphatase, Casein,Phosphatase, Ecto-Phosphoprotein,Phosphatase, Nuclear Protein,Phosphatase, Phosphohistone,Phosphatase, Phosphoprotein,Phosphatase, Phosphoseryl-Protein,Phosphatase, Protein,Phosphatase, Protein-Serine-Threonine,Phosphatase, Protein-Threonine,Phosphatase, Serine-Threonine,Phosphatase, Threonine,Phosphatase-2C, Phosphoprotein,Phosphatases, Phosphoprotein,Phosphatases, Protein,Phosphohydrolase, Phosphoprotein,Phosphoprotein Phosphatase 2C,Phosphoseryl Protein Phosphatase,Protein Phosphatase C I,Protein Phosphatase C II,Protein Phosphatase H II,Protein Phosphatase, Nuclear,Protein Serine Threonine Phosphatase,Protein Threonine Phosphatase,Serine Threonine Phosphatase
D010766	Phosphorylation	The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.	Phosphorylations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001345	Autoradiography	The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)	Radioautography
D012441	Saccharomyces cerevisiae	A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.	Baker's Yeast,Brewer's Yeast,Candida robusta,S. cerevisiae,Saccharomyces capensis,Saccharomyces italicus,Saccharomyces oviformis,Saccharomyces uvarum var. melibiosus,Yeast, Baker's,Yeast, Brewer's,Baker Yeast,S cerevisiae,Baker's Yeasts,Yeast, Baker
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D054645	Protein Phosphatase 1	A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.	PP1c Enzyme,Phosphoprotein Phosphatase-1 delta,Phosphoprotein Phosphatase-1 gamma 1,Protein Phosphatase 1, Catalytic Subunit,Protein Phosphatase 1, Catalytic Subunit, alpha Isoform,Protein Phosphatase 1, Catalytic Subunit, beta Isoform,Protein Phosphatase 1, Catalytic Subunit, delta Isoform,Protein Phosphatase 1, Catalytic Subunit, gamma Isoform,Protein Phosphatase 1, Catalytic Subunit, gamma1 Isoform,Protein Phosphatase 1, Catalytic Subunit, gamma2 Isoform,Protein Phosphatase 1, Inhibitory Subunit,Protein Phosphatase 1, Regulatory Subunit,Protein Phosphatase 1C,Protein Phosphatase 1C gamma,Protein Phosphatase 1gamma,Protein Phosphatase-1,Protein Phosphatase-1 alpha,Protein Phosphatase-1 gamma 2,Protein Phosphatase-1G,Protein Serine-Threonine Phosphatase 1 beta,Protein-Serine-Threonine Phosphatase 1 beta,Type 1 Serine Threonine Protein Phosphatase,Phosphatase-1 delta, Phosphoprotein,Phosphoprotein Phosphatase 1 delta,Phosphoprotein Phosphatase 1 gamma 1,Protein Phosphatase 1 alpha,Protein Phosphatase 1 gamma 2,Protein Phosphatase 1G,Protein Serine Threonine Phosphatase 1 beta