Biomaterial Database

Fibroblast anchorage to microtextured surfaces. 1993

J Meyle, and K Gültig, and H Wolburg, and A F von Recum

Sonderforschungsbereich Implantology, Poliklinik für Zahnärztliche Chirurgie und Parodontologie, Tübingen, Germany.

The contact between tissue and the implanted biomaterial is influenced by the micromorphology of the implant surface as well as biomechanical reactions. This effect is mediated by subcellular morphological structures and can affect the anchorage of the material inside the body of the host. The aim of the present study was to ascertain by transmission electron microscopy how human gingival fibroblasts interact with surface events. A special replica technique was used to produce a line pattern of 1 micron pitch with a depth of 1 micron. It was demonstrated, by transmission electron microscopy, that cells seeded on this surface extended cellular processes into the grooves, leading to an intensive contact and probably to mechanical interlocking. The typical morphological structures at several points indicated the presence of focal adhesion sites.

UI	MeSH Term	Description	Entries
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D010796	Phthalic Anhydrides	Phthalic acid anhydrides. Can be substituted on any carbon atom. Used extensively in industry and as a reagent in the acylation of amino- and hydroxyl groups.	Anhydrides, Phthalic
D002448	Cell Adhesion	Adherence of cells to surfaces or to other cells.	Adhesion, Cell,Adhesions, Cell,Cell Adhesions
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D004853	Epoxy Resins	Polymeric resins derived from OXIRANES and characterized by strength and thermosetting properties. Epoxy resins are often used as dental materials.	Epoxy Resin,Resin, Epoxy,Resins, Epoxy
D005347	Fibroblasts	Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.	Fibroblast
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001672	Biocompatible Materials	Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.	Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible
D001696	Biomechanical Phenomena	The properties, processes, and behavior of biological systems under the action of mechanical forces.	Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic
D013499	Surface Properties	Characteristics or attributes of the outer boundaries of objects, including molecules.	Properties, Surface,Property, Surface,Surface Property