Changes in skin blood flow in ischaemic limbs after vascular reconstruction measured by fluorescein flowmetry and laser Doppler flowmetry. 1993

E Proano, and L Perbeck
Department of Surgery, Huddinge University Hospital, Sweden.

It is not known to what extent the skin blood flow increases after vascular reconstruction in ischaemic limbs. Thus, a study was undertaken to measure skin blood flow, using the two techniques laser Doppler flowmetry and fluorescein flowmetry, before and after vascular reconstruction. The skin temperature was measured also. The plantar circulation was assessed in 14 patients (9 non-diabetics and 5 diabetics; mean age 65 years; range 47-80), with the patient in the supine position, 1-2 days before and 8-10 days after surgery. After vascular reconstruction the skin blood flow increased by 240% (P < 0.01) when measured by fluorescein flowmetry and by 148% (P < 0.01) when measured by laser Doppler flowmetry, and the skin temperature rose by 3.2 degrees C (P < 0.01). In the contralateral non-operated limb there was no significant change in skin blood flow as measured by the two methods. The results imply that after vascular reconstruction in ischaemic limbs the skin blood flow increases both in the superficial layer as determined by fluorescein flowmetry (which measures the blood flow down to 0.6 mm) and in deeper layers as determined by laser Doppler flowmetry (which measures flux down to 6 mm).

UI MeSH Term Description Entries
D007511 Ischemia A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. Ischemias
D007866 Leg The inferior part of the lower extremity between the KNEE and the ANKLE. Legs
D008833 Microcirculation The circulation of the BLOOD through the MICROVASCULAR NETWORK. Microvascular Blood Flow,Microvascular Circulation,Blood Flow, Microvascular,Circulation, Microvascular,Flow, Microvascular Blood,Microvascular Blood Flows,Microvascular Circulations
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011184 Postoperative Period The period following a surgical operation. Period, Postoperative,Periods, Postoperative,Postoperative Periods
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D005452 Fluoresceins A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays. Tetraiodofluorescein
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

E Proano, and L Perbeck
April 1987, Clinical physiology (Oxford, England),
E Proano, and L Perbeck
January 1987, International journal of microcirculation, clinical and experimental,
E Proano, and L Perbeck
June 1994, Hearing research,
E Proano, and L Perbeck
January 1995, Clinics in dermatology,
E Proano, and L Perbeck
February 2003, Dental traumatology : official publication of International Association for Dental Traumatology,
E Proano, and L Perbeck
March 1999, Microvascular research,
E Proano, and L Perbeck
January 1984, Archives of dermatological research,
E Proano, and L Perbeck
April 1999, Psychiatry and clinical neurosciences,
Copied contents to your clipboard!