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The blood pressure lowering effects of prindolol (2 x 5 mg daily) and of the combination prindolol (2 x5 mg) + clopamide (10 mg) were investigated in a single blind controlled study on 61 patients with slight hypertension and compared with placebo in another group of patients. In both groups, a significant lowering of blood pressure, both lying down and standing, could be achieved, the fall in blood pressure in standing being significantly better with the combination treatment. The number of responders was greater with the combination therapy than with prindolol alone.
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