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We studied the interaction between free fatty acids (FFAs) and arginine (ARG) on basal and growth hormone (GH)-releasing hormone (GHRH)-stimulated GH secretion in 14 normal subjects. Compared with placebo, ARG induced a significant increase of GH secretion (334.0 +/- 157.5 v 36.9 +/- 27.6 micrograms/L/h, P < .05). The increased levels of FFAs (1.9 +/- 0.4 mEq/L), obtained by the infusion of a lipid-heparin emulsion, abolished the effect of ARG (55.8 +/- 45.6 v 334.0 +/- 157.5 micrograms/L/h, P < .05). GHRH-induced GH secretion was potentiated by ARG (2,009.9 +/- 463.2 v 922.0 +/- 244.4 micrograms/L/h, P < .05) and suppressed by lipid-heparin infusion (106.2 +/- 28.3 v 922.0 +/- 244.4 micrograms/L/h, P < .01). Moreover, the lipid-heparin infusion inhibited the potentiating effect of ARG on the GHRH-induced GH increase (527.9 +/- 113.6 v 2,009.9 +/- 463.2 micrograms/L/h, P < .01). These results confirm the strong inhibitory effect of FFAs on GH secretion, showing that they are even able to inhibit the potentiating effect of ARG on the GH response to GHRH. Since ARG likely acts via inhibition of hypothalamic somatostatin release, the inhibitory effect of FFAs on GH secretion could take place directly at the pituitary level and/or at the hypothalamic level, counteracting the effect of ARG.
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
September 1972,
The Journal of clinical investigation,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
February 1985,
The Journal of clinical endocrinology and metabolism,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
June 1972,
Metabolism: clinical and experimental,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
April 1990,
Endocrinology,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
January 1972,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
October 1987,
The Journal of clinical endocrinology and metabolism,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
July 1989,
Endocrinology,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
February 1977,
Revista clinica espanola,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
October 1970,
Endocrinologia japonica,
M Maccario, and
M Procopio, and
S Loche, and
M Cappa, and
V Martina, and
F Camanni, and
E Ghigo
December 1973,
Revista espanola de fisiologia,
