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9 rabbits were immunized with the synovial fluid of patients with rheumatoid arthritis. The antisera thus raised contained antibodies against 18 serum proteins and against fibrinogen. After full absorption of the antisera with human blood plasma a maximum of 5 and average of 3 typically synovial antigens could be detected in the synovial fluid by immunodiffusion. One antigen (SF1) was present in all studied human organs and connective tissue extracts. It is thermostable, insoluble in alcohol, but soluble in 0,3 N perchloric acid. The two other antigens had a lipid character, one of them was also thermostable and insoluble in alcohol and smaller amounts there-of were found in organ extracts. The antigens could also be detected in synovial effusions caused by trauma, whereas normal synovial fluid contained only two unidentified antigens in low titre. Using immunodiffusion the antisera did not show any cross reaction with synovial fluids and organ extracts of other species. Immuno-electrophoretically only the line of the SF1 in the alpha1/alpha2 area could be definitely localized.
K Abendroth, and
K Thoss
January 1964,
Annals of the rheumatic diseases,
K Abendroth, and
K Thoss
January 1975,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
K Abendroth, and
K Thoss
January 1949,
Helvetica physiologica et pharmacologica acta,
K Abendroth, and
K Thoss
May 1962,
Proceedings of the staff meetings. Mayo Clinic,
K Abendroth, and
K Thoss
January 1961,
Medycyna doswiadczalna i mikrobiologia,
K Abendroth, and
K Thoss
February 1968,
Canadian journal of microbiology,
K Abendroth, and
K Thoss
October 1974,
Journal of the National Cancer Institute,
K Abendroth, and
K Thoss
January 1972,
The Biochemical journal,
K Abendroth, and
K Thoss
June 1968,
Fukushima journal of medical science,
K Abendroth, and
K Thoss
August 1975,
Journal of the National Cancer Institute,
