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The intragastric tube feeding model is ideal for the study of the role of dietary factors and the effect of drugs on experimental alcoholic liver disease (ALD), since the model allows us to study the effect of a single variable in the diet on the pathology of liver where the blood alcohol level (BAL) is maintained over 150 mg%. By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL. Concomitant with the increase in CYP2E1 there was evidence for an increase in lipid peroxidation (LP) by microsomes. Protein adducts of the products of LP were increased in the blood. Isoniazid (INH) enhanced this process and the pathology of ALD when INH was fed at therapeutic levels with ethanol. Preliminary studies show that diallyl sulfide, which inhibits and destroys liver CYP2E1 selectively, also modified the pathologic effects of ethanol. Thus we postulate that CYP2E1 induction plays a central role in the pathogenesis of ALD.
M Morimoto, and
A L Hagbjörk, and
A A Nanji, and
M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
S W French
January 2020,
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M Morimoto, and
A L Hagbjörk, and
A A Nanji, and
M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
S W French
January 2014,
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M Morimoto, and
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M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
S W French
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M Ingelman-Sundberg, and
K O Lindros, and
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E Albano, and
S W French
August 2009,
Hepatology (Baltimore, Md.),
M Morimoto, and
A L Hagbjörk, and
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M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
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November 1994,
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A L Hagbjörk, and
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M Ingelman-Sundberg, and
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P C Fu, and
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S W French
February 2003,
Hepatology (Baltimore, Md.),
M Morimoto, and
A L Hagbjörk, and
A A Nanji, and
M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
S W French
June 2001,
Alcoholism, clinical and experimental research,
M Morimoto, and
A L Hagbjörk, and
A A Nanji, and
M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
S W French
January 2019,
Zeitschrift fur Gastroenterologie,
M Morimoto, and
A L Hagbjörk, and
A A Nanji, and
M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
S W French
January 2013,
PloS one,
M Morimoto, and
A L Hagbjörk, and
A A Nanji, and
M Ingelman-Sundberg, and
K O Lindros, and
P C Fu, and
E Albano, and
S W French
December 2014,
World journal of gastroenterology,
