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Fawn-hooded (FH) rats with congenital proteinuria and systemic and glomerular hypertension are very susceptible to renal damage at a young age. In this study, the effects of unilateral nephrectomy (UNX) on the function and structure of the remaining kidney in the FHH substrain were assessed. A long-term study was performed to determine the changes in systemic blood pressure, renal function, and proteinuria during the development of chronic renal failure in UNX-FHH and two-kidney (2K) FHH rats. Renal micropuncture and morphologic studies were performed at 4 wk after surgery. The long-term study showed that, after UNX, systolic blood pressure did not differ significantly (from that of 2K-FHH rats. After UNX, there was compensatory hyperfiltration, at about 70% of the 2K level, that could be maintained for 12 wk only. The subsequent fall in GFR was preceded by severe proteinuria. The mean survival time of UNX-FHH rats was only 35 wk. Micropuncture studies showed that the high mean glomerular capillary pressure of 2K-FHH rats was further elevated after UNX. The glomerular capillary ultrafiltration coefficient did not differ significantly between UNX-FHH and 2K-FHH rats. The weight of the remaining kidney and the mean glomerular tuft volume in UNX-FHH were, on average, 36 and 31% greater than in 2K rats. The results indicate that the FHH rat is extremely vulnerable to the adverse renal effects of UNX.(ABSTRACT TRUNCATED AT 250 WORDS)
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
September 1978,
The American journal of pathology,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
January 1988,
Renal physiology and biochemistry,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
February 1994,
Kidney international. Supplement,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
December 1986,
Laboratory animal science,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
June 1992,
European journal of clinical investigation,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
January 1999,
The American journal of physiology,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
April 2005,
Journal of the American Society of Nephrology : JASN,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
March 1988,
Veterinary pathology,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
October 1986,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
J L Simons, and
A P Provoost, and
M H De Keijzer, and
S Anderson, and
H G Rennke, and
B M Brenner
April 1984,
British journal of experimental pathology,
