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Expression of CD45RA (naive) and CD45RO (memory) antigens in T-acute lymphoblastic leukaemia. 1993

R P Falcão, and A B Garcia
Department of Clinical Medicine, School of Medicine, Ribeirão Preto, Brazil.

We have determined the distribution of CD45RO (memory) and CD45RA (naive) antigens in the bone marrow blasts from 25 patients with T-acute lymphoblastic leukaemia (T-ALL). Four groups of patients were identified on the basis of reactivity with specific antibodies by flow cytometric analysis: (a) CD45RA-/CD45RO+ (16 patients): four CD4-/CD8+, seven CD4+/CD8+ and five CD4-/CD8-; (b) CD45RA+/CD45RO- (three patients): three CD4-/CD8-; (c) five CD45RA-/CD45RO-: one CD4+/CD8-; one CD4-/CD8+; three CD4+/CD8+; (d) CD45RA+/CD45RO+ (one case): CD4+/CD8-. There was no correlation between the expression of the naive and the memory phenotypes and the presence of CD4, CD8 or any other antigen except the CD10 antigen which was expressed by all CD45RA-/CD45RO- patients. The predominance of the CD45RA-/CD45RO+ phenotype (65%) and the low incidence of the hybrid phenotype CD45RA+/CD45RO+ (5%) in T-ALL, differs from the results reported by others for chronic or prolymphocytic T-cell leukaemias, in which the simultaneous expression of these maturational antigens was detected in approximately half of the cases.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000951 Antigens, Neoplasm Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin. Neoplasm Antigens,Tumor Antigen,Tumor Antigens,Antigen, Tumor,Antigens, Tumor

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