Biomaterial Database

Speech fluency in aphasia. Regional cerebral blood flow correlates of recovery using single-photon emission computed tomography. 1994

A G Mlcoch, and D L Bushnell, and S Gupta, and T J Milo

Audiology and Speech Pathology Service (126), Hines Veterans Affairs Hospital, IL 60141.

This study investigated the relationship between diminished regional cerebral blood flow (rCBF) and the recovery of fluent speech in aphasia. Single-photon emission computed tomographic brain scans using [123I]N-isopropyl-p-iodoamphetamine were obtained from 14 nonfluent aphasic patients within 30 days of cerebral infarction. Measurements of speech fluency were acquired initially and at 3 months after infarction. Nearly all of the patients exhibited significant hypoperfusion to combinations of the anterior and posterior regions of the basal ganglion, the periventricular white matter, and the inferior frontal regions. Only the inferior frontal area was significantly associated with recovery of fluent speech. This region was hypoperfused in 4 of 5 patients with poor recovery while 8 of the 9 patients with good speech fluency recovery demonstrated normal rCBF to the inferior frontal region.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002544	Cerebral Infarction	The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).	Anterior Choroidal Artery Infarction,Cerebral Infarct,Infarction, Cerebral,Posterior Choroidal Artery Infarction,Subcortical Infarction,Cerebral Infarction, Left Hemisphere,Cerebral Infarction, Right Hemisphere,Cerebral, Left Hemisphere, Infarction,Cerebral, Right Hemisphere, Infarction,Infarction, Cerebral, Left Hemisphere,Infarction, Cerebral, Right Hemisphere,Infarction, Left Hemisphere, Cerebral,Infarction, Right Hemisphere, Cerebral,Left Hemisphere, Cerebral Infarction,Left Hemisphere, Infarction, Cerebral,Right Hemisphere, Cerebral Infarction,Right Hemisphere, Infarction, Cerebral,Cerebral Infarctions,Cerebral Infarcts,Infarct, Cerebral,Infarction, Subcortical,Infarctions, Cerebral,Infarctions, Subcortical,Infarcts, Cerebral,Subcortical Infarctions
D002560	Cerebrovascular Circulation	The circulation of blood through the BLOOD VESSELS of the BRAIN.	Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D001037	Aphasia	A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.	Aphasia, Acquired,Dysphasia,Word Deafness,Alogia,Anepia,Aphasia, Ageusic,Aphasia, Auditory Discriminatory,Aphasia, Commisural,Aphasia, Functional,Aphasia, Global,Aphasia, Graphomotor,Aphasia, Intellectual,Aphasia, Mixed,Aphasia, Post-Ictal,Aphasia, Post-Traumatic,Aphasia, Progressive,Aphasia, Semantic,Aphasia, Syntactical,Dejerine-Lichtheim Phenomenon,Dysphasia, Global,Lichtheim's Sign,Logagnosia,Logamnesia,Logasthenia,Acquired Aphasia,Ageusic Aphasia,Ageusic Aphasias,Alogias,Anepias,Aphasia, Post Ictal,Aphasia, Post Traumatic,Aphasias, Commisural,Auditory Discriminatory Aphasia,Auditory Discriminatory Aphasias,Commisural Aphasia,Commisural Aphasias,Deafness, Word,Dejerine Lichtheim Phenomenon,Discriminatory Aphasia, Auditory,Discriminatory Aphasias, Auditory,Functional Aphasia,Functional Aphasias,Global Aphasia,Global Aphasias,Global Dysphasia,Global Dysphasias,Graphomotor Aphasia,Graphomotor Aphasias,Intellectual Aphasia,Intellectual Aphasias,Lichtheim Sign,Lichtheims Sign,Logagnosias,Logamnesias,Logasthenias,Mixed Aphasia,Mixed Aphasias,Phenomenon, Dejerine-Lichtheim,Post-Ictal Aphasia,Post-Ictal Aphasias,Post-Traumatic Aphasia,Post-Traumatic Aphasias,Progressive Aphasia,Progressive Aphasias,Semantic Aphasia,Semantic Aphasias,Sign, Lichtheim's,Syntactical Aphasia,Syntactical Aphasias
D013060	Speech	Communication through a system of conventional vocal symbols.	Public Speaking,Speaking, Public
D015899	Tomography, Emission-Computed, Single-Photon	A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.	CAT Scan, Single-Photon Emission,CT Scan, Single-Photon Emission,Radionuclide Tomography, Single-Photon Emission-Computed,SPECT,Single-Photon Emission-Computed Tomography,Tomography, Single-Photon, Emission-Computed,Single-Photon Emission CT Scan,Single-Photon Emission Computer-Assisted Tomography,Single-Photon Emission Computerized Tomography,CAT Scan, Single Photon Emission,CT Scan, Single Photon Emission,Emission-Computed Tomography, Single-Photon,Radionuclide Tomography, Single Photon Emission Computed,Single Photon Emission CT Scan,Single Photon Emission Computed Tomography,Single Photon Emission Computer Assisted Tomography,Single Photon Emission Computerized Tomography,Tomography, Single-Photon Emission-Computed