Biomaterial Database

[Response of thyrotropin (TSH) to the stimulation with hypothalamic releasing factor (TRF) in hypothyroid children]. 1975

E Avila, and M E Fucugauchi

The normal human serum thyrotropin (TSH) measured by radioimmunoassay in 36 children was 3.3 +/- 1.13 muUI/ml. No differences dependent on age or sex were found. Stimulation by intravenous injection of 100 mug of TRF has been carried out in 7 euthyroid children and in 14 with hypothyroidism. TSH was determined prior to, and during TRF stimulation. Among other thyroid tests included in this study were: serum T3 uptake, total thyroxine, serum protein-bound iodine, 131INa uptake and thyroid scanning. In the euthyroid children, TSH at zero time was 4.4 muUI/ml.; a significant increase was reached at 30-40 minutes. In 13 children with a light primary hypothyroidism, TSH was little increased in correlation with other parameters assessed. In two children with true primary hypothyroidism, TSH at zero time was X 465 muUI/ml., showing an increase at 30 minutes of X 550 muUL/ml. which was in agreement with the absence of thyroid tissue, showed by the scanning image and with the low concentration of thyroid hormones. The synthetic thyrotropin-releasing factor (TRF) should be a useful agent for clinical assessment of pituitary reserve. TSH, T3, T4 and T4I serum concentration measurement in pediatric age, makes possible to evaluate the physiopathology of the pituitary - thyroid axis.

UI	MeSH Term	Description	Entries
D007037	Hypothyroidism	A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.	Central Hypothyroidism,Primary Hypothyroidism,Secondary Hypothyroidism,TSH Deficiency,Thyroid-Stimulating Hormone Deficiency,Central Hypothyroidisms,Deficiency, TSH,Deficiency, Thyroid-Stimulating Hormone,Hormone Deficiency, Thyroid-Stimulating,Hypothyroidism, Central,Hypothyroidism, Primary,Hypothyroidism, Secondary,Hypothyroidisms,Primary Hypothyroidisms,Secondary Hypothyroidisms,TSH Deficiencies,Thyroid Stimulating Hormone Deficiency,Thyroid-Stimulating Hormone Deficiencies
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D013268	Stimulation, Chemical	The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.	Chemical Stimulation,Chemical Stimulations,Stimulations, Chemical