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Continuous infusion of cortisol into adrenalectomized fetal sheep during the last 72 h of gestation (term = 145 +/- 2 days) produced a significant (P < 0.05) rise in fetal serum tri-iodothyronine (T3) mean +/- S.E.M. concentrations from 398 +/- 65 to 1340 +/- 238 ng/l. A concurrent decrease in plasma thyroxine (T4) levels was observed in three out of four animals. No significant changes in the concentrations of either hormone were noted prior to the start of cortisol infusion. The plasma concentrations of cortisol, T3 and T4 at term were similar to those in untreated full-term lambs. Adrenalectomized fetuses not given cortisol infusions still had low levels of T3 at term, with no increase being observed. The results suggest that cortisol plays an important role in the increase of fetal plasma T3 observed towards the end of gestation. This is probably achieved by the stimulation of the monodeiodination of T4 to T3 in the peripheral tissues.
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
July 1989,
Journal of developmental physiology,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
October 2012,
Acta physiologica (Oxford, England),
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
July 1978,
Endocrinology,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
November 2001,
Brain research. Developmental brain research,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
July 1995,
The American journal of physiology,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
March 1998,
The American journal of physiology,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
January 2022,
Psychoneuroendocrinology,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
October 2003,
The Annals of pharmacotherapy,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
January 1992,
Cancer chemotherapy and pharmacology,
P L Sensky, and
C H Roy, and
R J Barnes, and
M F Heath
January 1999,
Domestic animal endocrinology,
