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We compared the effects of three dihydropyridine calcium antagonists (felodipine, nifedipine and amlodipine) on left ventricular (LV) contractile performance and diastolic filling dynamics in eight conscious animals. After administering metoprolol and atropine, felodipine (25 nmol/kg i.v.) produced significant decreases in LV end-systolic pressure (PES) (109 +/- 15 vs. 88 +/- 12 mmHg, P < .05) and arterial elastance (Ea) (12.6 +/- 4.5 vs. 8.5 +/- 3.4 mmHg/ml, P < .05), whereas the heart rate was unchanged. Felodipine increased the slopes of the end-systolic P-V relation (7.4 +/- 0.9 vs. 9.9 +/- 1.0 mmHg/ml, P < .05), the dP/dtmax-end diastolic volume (VED) relation (68.1 +/- 11.2 vs. 94.9 +/- 14.3 mmHg/sec/ml, P < .05), and the stroke work (SW)-VED relation (72.1 +/- 3.1 vs. 82.8 +/- 5.2 mmHg, P < .05), and shifted all three relations to the left, indicating enhanced contractile performance. In contrast, at doses that produced equivalent reductions of PES, nifedipine (375 nmol/kg i.v.) and amlodipine (780 nmol/kg i.v.), significantly decreased the slopes of the end-systolic P-V relation, the dP/dtmax-VED relation and the SW-VED relation and shifted all three relations to the right, indicating depressed LV contractile performance. Felodipine decreased the time constant (T) of LV relaxation (32.2 +/- 5.2 to 28.8 +/- 5.2 msec, P < .05) and increased the maximum rate of early diastolic LV filling (dV/dtmax) (167 +/- 22 to 207 +/- 26 ml/sec, P < .05). Amlodipine had the opposite effect, slowing T (31.0 +/- 4.9 to 33.9 +/- 5.4 msec, P < .05) and decreasing dV/dtmax (173 +/- 39 to 154 +/- 30 ml/sec, P < .05), whereas nifedipine had no significant effects on T, PGmax or dV/dtmax. Thus, we conclude that in conscious dogs after autonomic blockade, at dosages that produced equivalent arterial vasodilation, felodipine augmented, whereas amlodipine depressed, LV contractile performance, LV relaxation and early LV filling. Nifedipine decreased LV contractile performance but had no significant effect on LV relaxation and early LV filling.
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
June 1987,
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C P Cheng, and
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M Nordlander, and
M Ohno, and
W C Little
July 1994,
American heart journal,
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
December 2000,
Current problems in cardiology,
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
December 1994,
The Journal of pharmacology and experimental therapeutics,
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
October 1984,
Kaku igaku. The Japanese journal of nuclear medicine,
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
June 1994,
The American journal of physiology,
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
October 2003,
Heart (British Cardiac Society),
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
April 1992,
The American journal of cardiology,
C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
January 1990,
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C P Cheng, and
T Noda, and
M Nordlander, and
M Ohno, and
W C Little
October 1992,
The Journal of thoracic and cardiovascular surgery,
