BIOMAT Database Logo BIOMAT Database Logo

Clinical characteristics of patients with concurrent major depressive disorder and panic disorder. 1994

L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Department of Psychiatry, University of Michigan.

OBJECTIVE This study was designed to test the hypothesis that patients with both major depressive disorder and panic disorder exhibit more clinical symptoms and have a more protracted course of illness than patients with major depressive disorder only. METHODS The authors compared standardized clinical evaluations (from Schedule for Affective Disorders and Schizophrenia interviews) of 119 patients with major depressive disorder only and 57 patients with major depressive disorder and concurrent panic disorder. Clinical and demographic variables were included. RESULTS The patients with both disorders reported symptoms of major depressive disorder earlier in life and also required treatment and hospital admission earlier in life. Many clinical features during the index episode were significantly more severe in the patients with both disorders. A logistic regression identified a "panic index" consisting of the symptoms of somatic anxiety, phobia, indecisiveness, and feelings of inadequacy. Scores on this index allowed proper classification of patients to either of the two diagnostic groups with high reliability. CONCLUSIONS In major depressive disorder, the presence of panic disorder is suggestive of a more severe and precocious form of illness.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011569 Psychiatric Status Rating Scales Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness. Factor Construct Rating Scales (FCRS),Katz Adjustment Scales,Lorr's Inpatient Multidimensional Psychiatric Rating Scale,Wittenborn Scales,Edinburgh Postnatal Depression Scale,Mini International Neuropsychiatric Interview
D003866 Depressive Disorder An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. Depression, Endogenous,Depression, Neurotic,Depression, Unipolar,Depressive Syndrome,Melancholia,Neurosis, Depressive,Unipolar Depression,Depressions, Endogenous,Depressions, Neurotic,Depressions, Unipolar,Depressive Disorders,Depressive Neuroses,Depressive Neurosis,Depressive Syndromes,Disorder, Depressive,Disorders, Depressive,Endogenous Depression,Endogenous Depressions,Melancholias,Neuroses, Depressive,Neurotic Depression,Neurotic Depressions,Syndrome, Depressive,Syndromes, Depressive,Unipolar Depressions
D005260 Female Females
D006760 Hospitalization The confinement of a patient in a hospital. Hospitalizations
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D012720 Severity of Illness Index Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder. Illness Index Severities,Illness Index Severity

Related Publications

L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Clinical characteristics of patients with diagnostic uncertainty of major depressive disorder.
December 2017, Asian journal of psychiatry,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Comorbidity of panic and major depressive disorder.
January 1993, Journal of psychiatric research,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Delimitation of generalized anxiety disorder: clinical comparisons with panic and major depressive disorders.
January 1990, Comprehensive psychiatry,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Heart rate variability in drug-naïve patients with panic disorder and major depressive disorder.
November 2009, Progress in neuro-psychopharmacology & biological psychiatry,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Alexithymia and emotional intelligence in patients with panic disorder, generalized anxiety disorder and major depressive disorder.
September 2013, The Psychiatric quarterly,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Specificity of lactate response in panic disorder, panic with concurrent depression and major depression.
January 1989, Journal of affective disorders,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorder.
December 2004, The Journal of clinical psychiatry,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Differential responses to anxiogenic challenge studies in patients with major depressive disorder and panic disorder.
July 1990, Biological psychiatry,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder.
October 2006, Journal of affective disorders,
L Grunhaus, and A C Pande, and M B Brown, and J F Greden
Clinical and psychobiological characteristics of simultaneous panic disorder and major depression.
October 1988, The American journal of psychiatry,
Copied contents to your clipboard!