Biomaterial Database

Sleep deprivation in the rat at different ambient temperatures: effect on sleep, EEG spectra and brain temperature. 1994

I Tobler, and P Franken, and B Gao, and K Jaggi, and A A Borbély

Institute of Pharmacology, University of Zürich, Switzerland.

To investigate the relationship between thermoregulation and sleep regulation, rats were sleep-deprived for 3 hours at two different ambient temperatures. Sleep deprivations (SD) were performed at 23 degrees C (SD-23) and at 32 degrees C (SD-32) in the beginning of the 12-h light period in animals chronically implanted with ECoG and EMG electrodes, and with epidural and hypothalamic thermistors. SD-32 enhanced cerebral temperature more than SD-23 at both brain sites. The SD-induced hyperthermia was followed by a fall of brain temperature below baseline. During recovery from either SD procedure, waking was reduced and sleep continuity increased. REM sleep was increased after SD-32. EEG slow-wave activity (spectral power density in the 0.75-4.0 Hz band) exceeded the baseline level in the first 3-h interval of recovery; however, the effects of SD-23 and SD-32 did not differ. In the same time interval, power density in the 1.25-1.5 Hz bin as well as in some bins in the theta and alpha band was higher after SD-32 than after SD-23. The increase in hypothalamic temperature during SD did not correlate with the increase in SWA during recovery. It is concluded that even a brief SD has major repercussions on recovery sleep whereas the extent of cerebral hyperthermia during SD is only a minor factor.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D001831	Body Temperature	The measure of the level of heat of a human or animal.	Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D004569	Electroencephalography	Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.	EEG,Electroencephalogram,Electroencephalograms
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012890	Sleep	A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.	Sleep Habits,Sleeping Habit,Sleeping Habits,Habit, Sleep,Habit, Sleeping,Habits, Sleep,Habits, Sleeping,Sleep Habit
D012892	Sleep Deprivation	The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.	Inadequate Sleep,Insufficient Sleep,Insufficient Sleep Syndrome,REM Sleep Deprivation,Sleep Debt,Sleep Fragmentation,Sleep Insufficiency,Deprivation, REM Sleep,Deprivation, Sleep,Fragmentation, Sleep,Insufficiencies, Sleep,Insufficiency, Sleep,Insufficient Sleep Syndromes,Sleep Deprivation, REM,Sleep Insufficiencies,Sleep, Inadequate,Sleep, Insufficient,Syndrome, Insufficient Sleep
D012895	Sleep, REM	A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.	Fast-Wave Sleep,Paradoxical Sleep,Rapid Eye Movements,Rhombencephalic Sleep,Sleep, Fast-Wave,REM Sleep,Eye Movement, Rapid,Eye Movements, Rapid,Fast Wave Sleep,Movement, Rapid Eye,Movements, Rapid Eye,Rapid Eye Movement,Sleep, Fast Wave,Sleep, Paradoxical,Sleep, Rhombencephalic
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures
D017207	Rats, Sprague-Dawley	A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.	Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats