BIOMAT Database Logo BIOMAT Database Logo

Neonatal lupus erythematosus. Report of serological and immunogenetic studies in twins discordant for congenital heart block. 1994

R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.

Autoantibody, HLA studies and C4 phenotypes were performed on twins discordant for isolated congenital heart block. Serum from the mother and cord blood from the infants revealed Ro(SSA) and La(SSB) antibodies in all three sera. No significant difference in Ro(SSA) antibody titre was noted in the cord blood of either twin when compared with maternal titres, as detected by a sensitive ELISA assay. The infants' mother was HLA-DR3 positive. Both infants had identical HLA and C4 phenotypes. Immunoblot analysis revealed that sera from both mother and infants reacted with the 52-kDa Ro(SSA) macromolecule. Quantitative cord blood IgM levels were not elevated in either twin. This study indicates that placental transfer of anti-Ro(SSA) or anti-La(SSB) alone to the fetus is not sufficient for the expression of congenital complete heart block. We conclude from this experiment of Nature that there must be a second event determining which infant develops complete heart block, but this is unknown at present.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008178 Lupus Erythematosus, Cutaneous A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute ( Lupus Erythematosus, Cutaneous, Subacute,Lupus Erythematosus, Subacute Cutaneous,Cutaneous Lupus Erythematosus
D008297 Male Males
D003181 Complement C4 A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B. C4 Complement,C4 Complement Component,Complement 4,Complement C4, Precursor,Complement Component 4,Pro-C4,Pro-complement 4,C4, Complement,Complement Component, C4,Complement, C4,Component 4, Complement,Component, C4 Complement,Pro C4,Pro complement 4
D004200 Diseases in Twins Disorders affecting TWINS, one or both, at any age. Diseases in Twin,Twin, Diseases in,Twins, Diseases in,in Twin, Diseases,in Twins, Diseases
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006327 Heart Block Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects. Auriculo-Ventricular Dissociation,A-V Dissociation,Atrioventricular Dissociation,A V Dissociation,A-V Dissociations,Atrioventricular Dissociations,Auriculo Ventricular Dissociation,Auriculo-Ventricular Dissociations,Block, Heart,Blocks, Heart,Dissociation, A-V,Dissociation, Atrioventricular,Dissociation, Auriculo-Ventricular,Dissociations, A-V,Dissociations, Atrioventricular,Dissociations, Auriculo-Ventricular,Heart Blocks
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Neonatal lupus erythematosus with congenital heart block in twins.
July 2016, La Tunisie medicale,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Maternal and sibling microchimerism in twins and triplets discordant for neonatal lupus syndrome-congenital heart block.
February 2005, Rheumatology (Oxford, England),
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Congenital heart block in neonatal lupus erythematosus.
February 2009, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Discordant disease expression of neonatal lupus erythematosus in twins.
June 2017, JPMA. The Journal of the Pakistan Medical Association,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Monozygotic twins discordant for congenital complete heart block.
February 1997, Arthritis and rheumatism,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
[Cutaneous neonatal lupus erythematosus: discordant expression in identical twins].
October 2000, Annales de dermatologie et de venereologie,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Neonatal lupus erythematosus with congenital heart block associated with maternal systemic lupus erythematosus.
December 1986, Clinical rheumatology,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Neonatal lupus erythematosus complicated by improved congenital complete heart block.
August 2013, Pediatrics international : official journal of the Japan Pediatric Society,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Monozygotic twins discordant for systemic lupus erythematosus.
January 1975, Arthritis and rheumatism,
R M Watson, and J N Scheel, and M Petri, and J S Kan, and T T Provost, and H Ratrie, and N A Callan
Clinical and immunologic studies in identical twins discordant for systemic lupus erythematosus.
August 1973, The American journal of medicine,
Copied contents to your clipboard!