Production of additional squalestatin analogues by directed biosynthesis. 1994

R J Cannell, and M J Dawson, and R S Hale, and R M Hall, and D Noble, and S Lynn, and N L Taylor
Department of Natural Products Discovery, Glaxo Group Research Ltd., Greenford, Middlesex, U.K.

UI MeSH Term Description Entries
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D005285 Fermentation Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID. Fermentations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001643 Bridged Bicyclo Compounds Saturated alicyclic hydrocarbon molecules consisting of two rings that have two non-adjacent atoms in common. Bicyclo Compounds,Bicyclo Compounds, Bridged
D013186 Farnesyl-Diphosphate Farnesyltransferase The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway. Squalene Synthetase,FPP-FPP Farnesyl Transferase,Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase,Presqualene-Diphosphate Synthase,Squalene Synthase,FPP FPP Farnesyl Transferase,Farnesyl Diphosphate Farnesyltransferase,Farnesyl Transferase, FPP-FPP,Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase,Farnesyltransferase, Farnesyl-Diphosphate,Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate,Presqualene Diphosphate Synthase,Synthase, Presqualene-Diphosphate,Synthase, Squalene,Synthetase, Squalene,Transferase, FPP-FPP Farnesyl
D014233 Tricarboxylic Acids Organic compounds that are acyclic and contain three acid groups. A member of this class is citric acid which is the first product formed by reaction of pyruvate and oxaloacetate. (From Lehninger, Principles of Biochemistry, 1982, p443) Tricarboxylic Acid,Acid, Tricarboxylic,Acids, Tricarboxylic
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D019086 Bridged Bicyclo Compounds, Heterocyclic Heterocyclic compounds that contain two rings that share two non-adjacent atoms in common. Bicyclo Compounds, Heterocyclic,Heterocyclic Cpds, Bicyclic,Bicyclic Heterocyclic Compounds,Heterocyclic Bicyclo Compounds,Bicyclic Heterocyclic Cpds,Heterocyclic Compounds, Bicyclic

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