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The inhibitory effect of alpha-tocopherol on methemoglobin formation in normal and acatalasemic mice was studied by exposing their hemolysates to nitric oxide. Methemoglobin formation in normal and acatalasemic mouse hemolysates exposed to nitric oxide were significantly inhibited by the addition of alpha-tocopherol at final concentrations ranging from 1.2 to 5.8 mM. Negative correlations were observed between the logarithm of alpha-tocopherol concentration and the methemoglobin formation. The formation of methemoglobin in acatalasemic mouse hemolysates was greater than that in normal mouse hemolysates with or without added alpha-tocopherol. The methemoglobin formation in acatalasemic mice was also significantly inhibited by addition of more than 500 units/ml of catalase, and the methemoglobin formation in normal and acatalasemic mice was also inhibited with sodium diethyldithiocarbamate at a final concentration of 1 M.
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
January 1980,
Industrial health,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
August 1991,
Acta medica Okayama,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
January 2020,
Toxicology reports,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
March 1961,
Rassegna di fisiopatologia clinica e terapeutica,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
December 2004,
Annals of the New York Academy of Sciences,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
January 2003,
European journal of biochemistry,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
October 1996,
Bioorganic & medicinal chemistry,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
April 2008,
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
January 1993,
Ukrainskii biokhimicheskii zhurnal (1978),
L X Zhen, and
K Ishii, and
K Taketa, and
M Ogata
May 1995,
FEBS letters,
