Biomaterial Database

Coagulation studies in very low-birthweight infants. 1994

J H Seguin, and W H Topper

Kansas University Children's Center, Department of Pediatrics, University of Kansas Medical Center, Kansas City.

Reference values for coagulation studies of premature infants (24 to 29 weeks' gestational age) are needed for the management of hemostatic disorders in the precariously ill infant. We collected data on the very low-birthweight infants admitted to our intensive care nursery who met criteria over a 4-year period to determine prothrombin time, activated partial thromboplastin time, and fibrinogen levels in this group. Fifty-two infants had a mean prothrombin time of 14.5 seconds, a mean activated partial thromboplastin time of 69.5 seconds, and a mean fibrinogen level of 1.35 g/L. Converting values to ratios of adult control values facilitated direct comparison of results to published reference ranges. Coagulation studies may vary over a broad range of prematurity, and normal ranges are needed for prospective, randomized protocols designed to prevent the complications of abnormal coagulation function.

UI	MeSH Term	Description	Entries
D007230	Infant, Low Birth Weight	An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less.	Low Birth Weight,Low-Birth-Weight Infant,Birth Weight, Low,Birth Weights, Low,Infant, Low-Birth-Weight,Infants, Low-Birth-Weight,Low Birth Weight Infant,Low Birth Weights,Low-Birth-Weight Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007234	Infant, Premature	A human infant born before 37 weeks of GESTATION.	Neonatal Prematurity,Premature Infants,Preterm Infants,Infant, Preterm,Infants, Premature,Infants, Preterm,Premature Infant,Prematurity, Neonatal,Preterm Infant
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001777	Blood Coagulation	The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.	Blood Clotting,Coagulation, Blood,Blood Clottings,Clotting, Blood
D001780	Blood Coagulation Tests	Laboratory tests for evaluating the individual's clotting mechanism.	Coagulation Tests, Blood,Tests, Blood Coagulation,Blood Coagulation Test,Coagulation Test, Blood,Test, Blood Coagulation
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man