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The DR haplotypes of the human major histocompatibility complex have been arranged in five haplotypic groups based on genomic cloning and sequence analyses. To date, the expressed DRB sequences have been assigned to four different loci: DRB1, 3, 4 and 5. DRB1 alleles are present in all haplotypes, whereas DRB3, 4 and 5 are present only in some haplotypes. Here, Göran Andersson and colleagues suggest that DRB3, 4 and 5 sequences may be treated as a single allelic series. They argue that such a model is appropriate, since DRB3, 4 and 5 sequences are inherited in an allelic fashion, have similar genomic localization, exhibit similar levels of gene expression and are, with a few rare exceptions, not present in the same haplotype.
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
December 2012,
Molecular biology and evolution,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
November 1996,
Human immunology,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
January 1991,
International journal of cancer. Supplement = Journal international du cancer. Supplement,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
January 1993,
Human immunology,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
August 2009,
Zhonghua yi xue za zhi,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
June 1996,
Journal of molecular evolution,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
January 1993,
Immunogenetics,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
January 1997,
Immunogenetics,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
January 2015,
American journal of rhinology & allergy,
G Andersson, and
L Andersson, and
D Larhammar, and
L Rask, and
S Sigurdardóttir
December 1994,
British journal of rheumatology,
