-transparent.png){kind=logo}
Impairment of cognitive abilities is a frequent and significant sequelae of traumatic brain injury (TBI). The purpose of this experiment was to examine the generality of the cognitive deficits observed after TBI. The performance of three tasks was evaluated. Two of the tasks (passive avoidance and a constant-start version of the Morris water maze) were chosen because they do not depend on hippocampal processing. The third task examined was the standard version of the Morris water maze which is known to rely on hippocampal processing. Rats were either injured at a moderate level (2.1 atm) of fluid percussion brain injury or surgically prepared but not injured (sham-injured control group). Nine days after fluid percussion injury, injured (n = 9) and sham-injured rats (n = 8) were trained on the one-trial passive avoidance task with retention assessed 24 h later. On days 11-15 following injury, injured (n = 9) and sham-injured (n = 8) rats were trained on a constant-start version of the Morris water maze that has the animals begin the maze from a fixed start position on each trial. Additional injured (n = 8) and sham-injured (n = 8) animals were trained on days 11-15 after injury on the standard (i.e. using variable start positions) version of the Morris water maze. The results of this experiment revealed that performance of the passive avoidance and the constant-start version of the Morris water maze were not impaired by fluid percussion TBI.(ABSTRACT TRUNCATED AT 250 WORDS)
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
January 2002,
Current treatment options in neurology,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
January 2019,
Frontiers in neurology,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
August 1999,
The New Zealand medical journal,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
January 2020,
Behavioural brain research,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
February 2024,
Medicina (Kaunas, Lithuania),
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
January 2022,
Frontiers in medicine,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
January 2013,
PloS one,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
May 2002,
Seminars in speech and language,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
August 2021,
Behavioural brain research,
R J Hamm, and
B G Lyeth, and
L W Jenkins, and
D M O'Dell, and
B R Pike
January 2023,
PLOS global public health,
